解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The goal of our study was to explore the effect of social isolation stress of varying durations on the plasma oxytocin (OT), messenger ribonucleic acid (mRNA) for oxytocin receptor (OTR), plasma arginine vasopressin (AVP) and mRNA for V1a receptor of AVP (V1aR) expression in the hypothalamus and heart of socially mono...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.02.007
更新日期:2013-05-01 00:00:00
abstract::Expression of the two gonadotropin-releasing hormone homologue peptides GnRHI and GnRHII and their receptor GnRHR has been demonstrated in a number of malignancies. In hormone-dependent breast cancer, GnRH analogs are used for therapy in premenopausal women. Gene expression of GnRHI, II and R was studied in breast bio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.12.016
更新日期:2013-04-01 00:00:00
abstract::Obestatin is a 23-amino-acid peptide originally regarded as an anorexigenic factor. However, most of the subsequent studies failed to confirm the initially reported anorexigenic properties of obestatin. Obestatin is incapable of crossing the blood brain barrier (BBB), which may affect its biological function. Here, we...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.01.004
更新日期:2013-04-01 00:00:00
abstract::Higher plasma copeptin level has been associated with poor outcomes of critical illness. The present study was undertaken to investigate the plasma copeptin concentrations in children with traumatic brain injury (TBI) and to analyze the correlation of copeptin with disease outcome. Plasma copeptin concentrations of 12...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.01.015
更新日期:2013-04-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP) enhances angiogenesis in rats with focal cerebral ischemia. In the present study, we investigated the molecular mechanism of the proangiogenic action of VIP using an in vitro ischemic model, in which rat brain microvascular endothelial cells (RBMECs) are subjected to oxygen and gluc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.01.007
更新日期:2013-04-01 00:00:00
abstract::Bacillus thuringiensis Cry toxins recognizes their target cells in part by the binding to glycosyl-phosphatidyl-inositol (GPI) anchored proteins such as aminopeptidase-N (APN) or alkaline phosphatases (ALP). Treatment of Tenebrio molitor brush border membrane vesicles (BBMV) with phospholipase C that cleaves out GPI-a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.05.019
更新日期:2013-03-01 00:00:00
abstract::Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.032
更新日期:2013-03-01 00:00:00
abstract::Venoms from cone snails (genus Conus) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as an emerging source of peptide-based therapeutics. Cone snails are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.002
更新日期:2013-03-01 00:00:00
abstract::As the frequent emergence of the resistant bacteria, the development of new agents with a new action mode attracts a great deal of interest. It is now widely accepted that antimicrobial peptides (AMPs) are promising alternatives to conventional antibiotics. In this study, antimicrobial peptide polybia-MPI and its anal...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.11.002
更新日期:2013-01-01 00:00:00
abstract::The neuropeptide Y system is known to have expanded in early vertebrate evolution. Three neuropeptide Y receptors have been proposed to have existed before the two basal vertebrate tetraploidizations, namely a Y1-like, a Y2-like, and a Y5-like receptor, with their genes in the same chromosomal region. Previously we ha...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.11.007
更新日期:2013-01-01 00:00:00
abstract::Neuropeptide S (NPS) produces several biological actions by activating a formerly orphan GPCR, now named NPS receptor (NPSR). It has been previously demonstrated that NPS stimulates murine leukocyte chemotaxis in vitro. In the present study we investigated the ability of NPS, in comparison with the proinflammatory pep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.10.013
更新日期:2013-01-01 00:00:00
abstract::An important question in contemporary sensory neuroscience is how animals perceive their environment and make appropriate behavioral choices based on chemical perceptions. The fruit fly Drosophila melanogaster exhibits robust tastant and odor-evoked behaviors. Understanding how the gustatory and olfactory systems supp...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2012.09.019
更新日期:2012-12-01 00:00:00
abstract::The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cel...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.024
更新日期:2012-12-01 00:00:00
abstract::Obestatin regulates fluid and electrolyte homeostasis mainly by opposing the action of vasopressin (AVP). We measured plasma concentration of obestatin and AVP in patients with cardiorenal syndrome (CRS). Plasma AVP and obestatin concentration were measured in 34 patients with type II CRS. The data were compared to th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.022
更新日期:2012-12-01 00:00:00
abstract::WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.021
更新日期:2012-11-01 00:00:00
abstract::Several studies have documented cardiovascular effects of apelin, including enhanced inotropy and vasodilation. However, these cardiovascular effects are short lived due to the predicted short circulating half-life of the apelin peptide. To address this limitation of apelin, we pursued N-terminal PEGylation of apelin ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.003
更新日期:2012-11-01 00:00:00
abstract::The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of O...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.005
更新日期:2012-11-01 00:00:00
abstract::Ureases (EC 3.5.1.5) are metalloenzymes that hydrolyze urea into ammonia and CO(2). These proteins have insecticidal and fungicidal effects not related to their enzymatic activity. The insecticidal activity of urease is mostly dependent on the release of internal peptides after hydrolysis by insect digestive cathepsin...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.010
更新日期:2012-11-01 00:00:00
abstract::Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue. No significant difference (P ≥ 0.05) was found for the XO inhibitory p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.030
更新日期:2012-10-01 00:00:00
abstract::This study aimed to examine the effects of CPB on salusin-α, salusin-β and apelin-36 bioactive peptides in people who are planned to undergo coronary artery bypass graft (CABG) operation due to coronary artery disease and to explore whether these peptides are produced in human aortic, saphenous and arterial tissues. T...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.027
更新日期:2012-10-01 00:00:00
abstract::Neuropeptide FF (NPFF) has been shown to act as an endogenous anti-analgesic peptide. In this paper, several peptide analogs of the selective ligand dNP(NMe)AFLFQPQRF-NH(2) modified in the putative address segment, were designed to be selective NPFF(2) receptor probes, synthesized and assayed. One peptide dA(NMe)AAFLF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.008
更新日期:2012-09-01 00:00:00
abstract::A putative genome duplication event within the Silurana lineage has given rise to the tetraploid Cameroon clawed frog Silurana epitropicalis (Fischberg, Colombelli, and Picard, 1982). Peptidomic analysis of norepinephrine-stimulated skin secretions of S. epitropicalis led to identification of 10 peptides with varying ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.005
更新日期:2012-09-01 00:00:00
abstract::Neuromedin B (NMB), which was originally isolated from porcine spinal cord, is a mammalian bombesin-related peptide that exerts various physiological effects. Previously, we observed expression of NMB in rib cartilage from chicken. Here, we report the initial attempt to elucidate the role of NMB in cartilage. We used ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.05.010
更新日期:2012-08-01 00:00:00
abstract::Antimicrobial peptides, molecules produced in many different organisms, have high biocidal activity against several microorganisms. However, several questions about these molecules remain unclear. Therefore, this report details a systematic survey of the literature on the use of antimicrobial peptides against oral pat...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2012.05.015
更新日期:2012-08-01 00:00:00
abstract::Three novel antimicrobial peptides designated ToAMP1, ToAMP2 and ToAMP3 were purified from Taraxacum officinale flowers. Their amino acid sequences were determined. The peptides are cationic and cysteine-rich and consist of 38, 44 and 42 amino acid residues for ToAMP1, ToAMP2 and ToAMP3, respectively. Importantly, acc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.05.009
更新日期:2012-08-01 00:00:00
abstract::One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.04.016
更新日期:2012-07-01 00:00:00
abstract::Obstructive jaundice (OJ) increases the risk of liver injury and sepsis, leading to increased mortality. Cholestatic liver injury is associated with a downregulation of hepcidin expression levels. In fact, hepcidin has an important antimicrobial effect, especially against Escherichia coli. It is unknown whether supple...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.03.032
更新日期:2012-06-01 00:00:00
abstract::This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfact...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.03.031
更新日期:2012-06-01 00:00:00
abstract::Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown. In rat, maternal treatment with a nitric oxide synthase inhibitor inducing hypertension was used to investigate apelin plasma levels in mother/fetus pairs and on the gene expression level of the apelin/...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.03.005
更新日期:2012-05-01 00:00:00
abstract::Neuronostatin is a 13-amino acid amidated peptide widely distributed in various organs including gastrointestinal tract. However, the effect of neuronostatin on gastrointestinal motility has not been well characterized. In the present work, effects of central administration of neuronostatin on gastric emptying and gas...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.03.013
更新日期:2012-05-01 00:00:00
abstract::Tight junctions (TJ) control paracellular permeability and apical-basolateral polarity of epithelial cells. Dysregulated permeability is associated with pathological conditions, such as celiac disease and inflammatory bowel disease. TJ formation is dependent on E-cadherin-mediated cell-cell adhesion and actin rearrang...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.02.016
更新日期:2012-05-01 00:00:00
abstract::Herein the effect of orexin receptor type-1 antagonist SB-334867 on the development of tolerance to analgesic effects of morphine was studied in rats. To incite tolerance, morphine sulfate was injected intraperitoneally (i.p., 10mg/kg) once a day for 7 days. The tail flick test was used to evaluate antinociceptive eff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.02.023
更新日期:2012-05-01 00:00:00
abstract::Ghrelin is broadly expressed in myocardial tissues, where it exerts different functions. It also has been found to have a wide variety of biological functions on cell differentiation and tissue development. The aim of this study was to investigate the effect of ghrelin on human embryonic stem cell (hESC) differentiati...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.02.006
更新日期:2012-04-01 00:00:00
abstract::In the adrenal gland all components of the renin-angiotensin system (RAS) are expressed in both the adrenal cortex and the adrenal medulla. In this review evidence shall be presented that a local secretory RAS exists in the adrenal cortex that stimulates aldosterone production and serves as an amplification system for...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2012.01.023
更新日期:2012-04-01 00:00:00
abstract::The chronic hyperglycemia measured alongside diabetes development is associated with significant long-term damage and failure of various organs. In the present study it was shown that hyperglycemia induced early and long term increases in nitric oxide (NO) levels, kallikrein activity and vascular capillary permeabilit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.02.008
更新日期:2012-04-01 00:00:00
abstract::Paramyosin of the pig-human parasite Taenia solium (TPmy) is a α-helical protein located on the worm surface that is suggested to fulfill an immunomodulatory role protecting the parasite against host immune system. Besides, in challenging experiments the protein shows a vaccine potential. These observations imply that...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.10.003
更新日期:2012-03-01 00:00:00
abstract::Huwentoxin-I (HWTX-I) is a 33-residue peptide isolated from the venom of Ornithoctonus huwena and could inhibit TTX-sensitive voltage-gated sodium channels and N-type calcium channels in mammalian dorsal root ganglion (DRG) neurons. However, the effects of HWTX-I on mammalian central neuronal and insect sodium channel...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.10.029
更新日期:2012-03-01 00:00:00
abstract::In the crayfish Astacus leptodactylus, as in several crustacean species, the crustacean hyperglycemic hormone is present as two isoforms differing by the chirality of the third residue, a phenylalanine. In the present work, isoforms synthesized full length by solid-phase peptide synthesis have been purified, refolded,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.01.019
更新日期:2012-03-01 00:00:00
abstract::A novel conotoxin, pc16a, was isolated from the venom of Conus pictus. This is the first peptide characterized from this South-African cone snail and it has only 11 amino acid residues, SCSCKRNFLCC*, with the rare cysteine framework XVI and a monoisotopic mass of 1257.6Da. Two peptides were synthesized with two possib...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.10.026
更新日期:2012-03-01 00:00:00
abstract::The distributions of neuropeptides in paraffin-embedded tissue sections (PETS) of the eyestalk, brain, and thoracic ganglia of the shrimp Penaeus monodon were visualized by imaging mass spectrometry (IMS). Peptide signals were obtained from PETS without affecting morphological features. Twenty-nine neuropeptides compr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.03.021
更新日期:2012-03-01 00:00:00